I think awareness by the caregivers is unlikely to have an effect on the biomarkers if the patients themselves are unaware.
Although it’s difficult to find. I believe this current data is from patients who do actually know they are receiving the drug and not a placebo.
“Preceding the placebo-controlled randomization of 15 patients, a 6 patient cohort underwent a 7-week pharmacokinetic (PK) assessment with safety, tolerability, pharmacokinetic and efficacy evaluation of ANAVEX®2-73”