Replies to post #208810 on Anavex Life Sciences Corp (AVXL)

[polarbear77]

Sure would appear to be, thanks for resending the link nidan.

This is yet another (big) reason the establishment may be interested in suppressing our progress/market cap:

“Sig-1R agonists are under intense investigation for the treatment of different neurodegenerative diseases, including AD and ALS [15,56,57]. It is actually the combination of receptor activities that may make ANAVEX2-73 an interesting compound for AD therapy [58] and, indeed, this compound is currently in active clinical studies in both neurodevelopmental (Rett syndrome) as well as neurodegenerative diseases (AD, PD). Based on the data presented here, the use of available Sig-1R agonists to stabilize protein homeostasis by promoting autophagy may represent an added value for such a treatment approach and strongly supports further clinical studies for prevention and treatment of neurodegeneration.

Taken together, to the best of our knowledge, this is the first report that Sig-1R activation (a) enhances the autophagic flux in human cells and in C. elegans, and (b) has positive effects on proteostasis. We described a novel activity of the compound ANAVEX2-73 having dual selective Sig-1R/muscarinic activities in neurons. The new activity of this drug comprises a potent induction of autophagy, in vitro and in vivo, leading to an increased proteostasis capacity, and even to beneficial effects on the time-dependent paralysis phenotype in Aß42-expressisng C. elegans. A specific induction of the autophagy process and a subsequent stabilization of the proteostasis in neurons represents one important concept towards the stabilization of neuronal survival and function, and may help to prevent age-associated neurodegeneration. Finally, the new finding presenting Sig-1R as a novel autophagy modulator may fuel future studies on Sig-1R, including the search for natural ligands to solve the sigma enigma.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468724/#!po=0.746269

“Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo”

https://www.globenewswire.com/news-release/2019/03/04/1745838/0/en/Anavex-Life-Sciences-Reports-Publication-of-New-Data-that-Show-ANAVEX-2-73-Induces-Cellular-Recycling-Process-Linked-to-the-Prevention-and-Treatment-of-Age-Associated-Diseases.html

[Boopka]

Nidan, funny you said that. It actually was my "Ahaaa" moment for Anavex. I read the Cells article three times just to make sure I comprehended everything. I also believe, as I believe you stated, that 2-73 is the functional equivalent of a CNS reset button that gets the body back to ground zero.
The possibilities may be endless. GLTA