Replies to post #212898 on Amarin Corp Plc (AMRN)

[jessellivermore]

Atom...

Sorry, I do not equate the term primary composite endpoint with primary events...

Primary events in my thinking means events in the primary prevention cohort..and secondary events refers to events in the secondary prevention group..

Also I am not aware of any grading system that measured event severity in the R-I trial...

I don't consider primary events the same thing as primary endpoints....

":>) JL

[sts66]

JL isn't confused about anything - Will is - this statement is the problem:

The numbers used in the math are for the primary events which I thought are non-fatal events. The secondary events include cv death and others and the risk % is even smaller, e.g., 3.5%

1. The numbers used were from the primary endpoint of R-IT. which was 5 pt MACE.

2. Primary events are defined as the first CVE a patient suffers - it's not JL's definition, it's a widely known and used definition in CVOTs. Same goes for the term secondary event - that's when a patient with established CVD that has already had at least one event has a second one, or 3rd, or 4th, etc., and it need not be an MI or stroke, it could be hospitalization from unstable angina. R-IT looked at secondary [event] prevention and primary [event] prevention - in practical use, you don't write the words contained in brackets.

3. The primary endpoint of R-IT included CV death, it's part of 5 pt MACE. The most important secondary endpoint was 3 pt MACE, which includes CV death - so Will' statement "The numbers used in the math are for the primary events which I thought are non-fatal events." contains two errors, the improper term used (events instead of endpoints) and "non-fatal", because obviously CV death is, erm.....fatal.