ghmm. Yes according to my wife it’s a very buyable argument . Dialysis patients on phosphate binders ( most are ) complain of constipation ... often only 2-3 bowel movements per week . When they add Tenapanor bowel movements may increase to 5-6 times a week . In my wife’s opinion most of her patients would consider this a good thing because it made them feel more “ normal “
The issue will be in the final P3 which is a mono therapy . There won’t be a binder to offset the “ loose stool “ ... so discontinue rate might be higher .
In end wife thinks it will be a blend of the 2 ... allowing patients to reduce the binders they are on when they add Tenapanor .... but not to the extent of causing diarrhea
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