Replies to post #207537 on Anavex Life Sciences Corp (AVXL)

[McMagyar]

very well written..thank you

[drv17]

In a quick glance through Anavex 2-73 was the only sigma 1 receptor mentioned that I saw.

Thank you for posting this Pineapple and Nidan

Excerpted from "frontiers in Nuroscience" article -
Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases
Role of S1R in Alzheimer’s Disease (AD)

Indeed, in vivo treatment of McGill-R-Thy1-APP transgenic rats also reduced amyloid burden and inflammation while enhancing synaptogenesis and cognition (Fisher et al., 2016). Another mixed muscarinic/s1R agonist, ANAVEX2-73, was able to mitigate Aß25–35-induced tau phosphorylation and Aß1–42 seeding in mice (Lahmy et al., 2013) and may help to preserve cognition in preliminary clinical trials clinical studies with AD patients (Macfarlane et al., 2016).

From Google search for AF710B -

Anavex Strengthens Alzheimer's Pipeline, Obtains Exclusive ...

https://globenewswire.com › news-release › 2014/03/31 › Anavex-Strengt...
Mar 31, 2014 - The licensing of AF710B complements Anavex's existing pipeline in Alzheimer's disease, which is the company's core competency and ...