Replies to post #210879 on Amarin Corp Plc (AMRN)

[jessellivermore]

Flubber....

I am not an expert on pulmonary embolism..The mechanism is blood clots build up in the deep veins of the legs which are about the diameter of your thumb...generally there is no swelling of the legs to give the victim any idea that a fatal event could be in the next minute or period of time..There could be a a lot of factors that trigger the process...

The blood flow in the veins is slow and not driven by the heart, but rather by leg muscle contraction and one way valves in the major deep veins of the lower extremities...So stagnation can led to coagulation, but it is not all that simple as the blood can stagnate for long periods of time with out coagulation being triggered...Virtually everyone has periods where there leg muscles are inactive..such as deep sleep and they do not suffer an embolus..The embolus itself is a blood clot and they can a foot or longer and a half an inch in diameter..and stop the blood flow into the area..They are are also pathophysiologically active and release inflammatory enzymes including apoptotic cytochimes...

It is possible that being on Vascepa that the high EPA content squelched the predictable fatal inflammatory response...Bfost probably knows more about this than I do...Maybe he will comment,,

":>) JL

[sts66]

All of that prolonged sweating may have dehydrated him and made his blood "thick", potentially making it more prone to clotting. The tests my internist runs on my at every appt. include a full page of tests that measure inflammation, platelet stuff, endothelial function, and myocardial function - too many biomarkers to list here - we monitor them carefully because a few are elevated and that increases my risk of stroke - they'd probably be useful to track the health of someone who has suffered a PE to see if drug therapy needs modification, but I sorta doubt most clinicians are familiar with more than a couple of the ones on that page, so the info may not be terribly useful to them despite that fact that it could be if they were more educated on what those biomarkers represent.