Replies to post #27778 on Marker Therapeutics Inc (MRKR)

[ridinbulls]

Nice find poods! This patient had 16 months of Folfirinox followed by the same maintenance for the next year. That puts things in perspective!

Article Abstract:

“Metastatic pancreatic adenocarcinoma confers a poor prognosis. Even with recent treatments, complete response of the disease is still very rare. In this case report, we present the case of a 67-yearold male with metastatic pancreatic adenocarcinoma who achieved a complete response lasting for more than three years after receiving induction chemotherapy with FOLFIRINOX for 16 months followed by same regimen maintenance for one year. Therefore, this evidence-based approach is recommended for highly selected patients with sustained responses to chemotherapy.”

[attilathehunt]

I wonder if we get another CR will PH issue a press release? IMO, that would be a material event and warrant a shout out to the world.

[hanscott]

Yeah that is a good one Poods, That's one I posted Sunday. And there's another case study another below.

A 3-year disease free survival in a patient with metastatic pancreatic adenocarcinoma following folfirinox chemotherapy: A case report.

"Complete response is a rare outcome in patients with metastatic pancreatic cancer. . . In our patient, a complete response was achieved after 35 cycles of FOLFIRINOX over 16 months. . .

To our knowledge, we present the first case of a patient with metastatic non-resectable adenocarcinoma of the exocrine pancreas to achieve a complete response and continues to be on a 3-year disease free survival after monotherapy with FOLFIRINOX."

http://www.alliedacademies.org/articles/a-3year-disease-free-survival-in-a-patient-with-metastatic-pancreatic-adenocarcinoma-following-folfirinox-chemotherapy-a-case-repo-10396.html#3

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This patient was also on chemo for years before the CR. This group used gemcitabine with other agents including platinum.

"The journey from diagnosis to remission in this patient took 4 years of persistent chemotherapy treatment."
https://www.hematologyandoncology.net/archives/may-2012/lessons-learned-from-a-complete-remission-of-advanced-metastatic-pancreatic-ductal-adenocarcinoma/

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Here's one on Folfirinox with a twist.

" (a patient) who achieved a complete response after initial chemotherapy with FOLFIRINOX followed by maintenance chemotherapy with irinotecan, leucovorin, and 5-fluorouracil (FOLFIRI) and who has not yet recurred after 3 years from the initial diagnosis of metastatic disease."

https://www.hindawi.com/journals/crionm/2015/659624/


http://pancreas.imedpub.com/elevenyear-survival-with-unresectable-metastatic-pancreaticcarcinoma-a-roadmap-to-longterm-survival-for-metastatic-disease.php?aid=21001
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