Very impressive review and astonishing that BP have so far managed to ignore the complexity and direct involvement of mitochondrial function to instead go directly after Amyloid plaque.
Note also the section on "Therapeutic strategies to improve mitochondrial dynamics and function", which starts with
non-pharmacological interventions. Among the latter, diet and exercise appear to directly improve multiple parameters of mitochondrial dynamics and function collectively referred to as mitochondrial fitness.
So easy for many of us to ignore and reach for the pills instead.