Replies to post #233303 on NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Not all GTRs are equal.

Right, but Dr. Ashkan had been using 5-ala since 2009. Unless he is someone prone to embellishment, which I do not believe, he is probably seeing that contrast (still blinded) of an even more complete total resection (not all GTRs are equal) likely combined with DCVax-L therapy. A long time ago, I told Pyrr DCVax-L is not the strongest tool NWBO has available in its tool kit, but it is the safest. Because of that, better GTRs are going to produce better results when combined with DCVax-L. Why? Because, imo, from some old research and inferences I made a long time ago, DCVax-L is best at killing cancer cells on the move, aka: mesenchymal cells. When you resect an even greater number of cells locally, the likely remainder are individual and small groupings of ambulatory cancer cells looking for a new home to set up shop. The remaining non-mesenchymal cells are also more vulnerable because the previous immunosuppressive tumor microenvironment is temporarily or in some cases permanently disabled, allowing the immune system to target these less mutated cells as well.

[trocprofit]

RE: NWBO is priced like this is the only chess move left and I'm fine with those odds. But is LL fooling herself into believing that the results shes seeing are due to dcvax? I say this with sincerity. Perhaps the patients would've rebooted their immune response after SOC anyway. 5 ALA would provide that chance to a natural recovery the same way it opens the door for dcvax. It also becomes easier to fool yourself when the benefit is seen in the mgmt methylated patients, which could be why she always has a frog in her throat when describing brads histology and mgmt +


I disagree. Look at the screenshot I took from the video. Based on all historical GBM data, where it is usually a 16 month death sentence, you can't have an anomaly in one trial, even blinded.



49% MGMT Methylated make it 3 years!
14% MGMT UNmeth make it 3 years vs. 3-5% SOC...LL's words. 3X-5X better