Charles,
As we in effect said on Twitter, and found no reason to continue the dialogue thereafter, a “tea leaves” reading of the REDUCE-IT K/M curves is incoherent, and “hokey”. Shouldn’t it be immediately obvious why such an unscientific “reading” of the curves has no basis in reality? The most obvious refutation of your claim is that any harm done to placebo group subjects would of course begin from time zero on the curve. Immediately, their risk changes upon entering the study and consuming mineral oil concurrently with cardiac medications. Their risk rate is higher and constant from then on.
You might have an interesting observation if they were already followed for years and then began taking MO in the study, and then we could view a curve that was -5 to 0 to +5 years, but of course we don’t have those data (not to mention we cannot see any of the censors on this plot, but that is another story).
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