Replies to post #232735 on NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Exactly, the point of the refreshes was blinded analysis. Why bother otherwise? If you look at articles on this stuff, blinded analysis is highly recommended if you still want to modify SAP at the end of a trial. It looks to me like NWBO changed course in 2015 but additionally decided to bait shorts, dilute Neil and leave longs in the dark whilst continuing to accumulate securities for themselves through debt financing and votes for options.

[longfellow95]

The data collection for the IA would be blinded. The company (via their CROs) collects it blinded and provides that to the DSMB. The DSMB obtains the keys from the outside party handling the randomization.

How wonderfully old-fashioned..
I hope they got a spare set cut, just in case.