Neil Woodford
17 Jan 2017 at 3:09 pm
Hi Mark,
Thank you for your comment. As you and many of our investors are aware, we based our original decision to invest in Northwest Biotherapeutics on its compelling science and its unique approach to harnessing the immune system to fight cancer. Clearly, since then, things have not proceeded as we had hoped they would but, thus far, we have not seen anything that would contradict our original hypothesis.
There are always many factors to consider when making an investment decision and my 30+ years of managing money have taught me many things, not least that you never stop learning from the investment decisions that you make. As I said at WPCT’s AGM in the summer, the decision to invest in Northwest was not an error in due diligence but an error of judgement on my part.
Every investment decision involves making judgements about risks and judgements about potential rewards and I have certainly learnt lessons from this episode. From the outset, I was aware of the potential governance issues at the company, but I underestimated the extent of them. Furthermore, I overestimated our ability to influence change at the company. We will always do everything that we can to ensure positive long-term outcomes for our investors, but this case study suggests that it is not always enough. The governance issues at Northwest Biotherapeutics have continued to conspire to shred investor confidence in the business.
Northwest has periodically raised further finance over the course of the last year or so, the proceeds of which we presume are being applied to continuing with the trials. We have not participated in any of these fundraisings and we still await a response to the investigation that we called for in late 2015. We have not had any meaningful contact with the Board for some time.
In a very recent press release, the company stated that it had completed the Phase III glioblastoma registration trial even though it had not been able to recruit the final 17 patients because of a regulatory intervention that the company never shed any light on. The total number of patients in the trial of 331 should, according to the company, be enough to power the study. We await the results of this study as well as the results of other studies, which have yet to read out.
From here, we wait and retain hope that at least one of the trials reads out positively. This is something which, given events, we would apply a lower probability to now but, nevertheless it is certainly possible.
Regards
Neil