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jessellivermore

03/25/19 11:32 PM

#183196 RE: Jeffkad #183194

Jeff...

Quote:..."I am one of those that has labeled AMRN a one drug wonder, and yet I fully understand the potential of Vascepa."

No you don't.

Let's get to the patents..I have already explained the fact that companies do need to rely on patents..Walmart and Amazon have no patent advantages.
Its the very size...the volume of their business that protects them...They can buy their products from the suppliers cheaper because the suppliers can't afford to lose their business...They can lock out competitors because they can buy cheaper which means they can sell cheaper....

CocaCola...Established around 1900...Was a headache remedy sold in drug stores..It had cocaine in the mix...Customer liked the stuff so much it became a beverage...Later they took out the cocaine...The patents are ancient history...Coke still maintains "Trade Secrets" (Amarin will too)..Coke also gets priority treatment from suppliers (who wants to be the guy who lost the Coke account)...And their volume means they don't have to charge high prices....

What you and most of market don't understand is that Vascepa is not like some drug that has a huge mark up...If you get ten million customers..a fraction of the potential...the company is sell 40 million Vascepa capsules a day and that is as long as the patient lives in most cases...You don't need to be John Bersford Tipton to know that if you are making as little as 50 cents a capsule that you are pulling in $20 mil a day in profits....

As far as a "one trick pony"...This drug has the potential to be therapeutic in 10 major ,medical conditions at minimum...and to be the top drug in that space...If you can't understand that...We have nothing to discuss..

Please if you have trouble with these explanations do not direct anymore posts toward me..Its a waste of our time...

":>) JL
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Whalatane

03/26/19 12:04 AM

#183198 RE: Jeffkad #183194

Jeff. If I may intervene
My understanding is that we have methods of action and methods of composition patents .
Right now Amarin is concentrating on the big cahona ...heart disease .
But there’s evidence Vascepa may be useful in treating dry eye problems and itching problems that many dialysis patients experience .
Amarin just needs to run the trials and file for the methods of action / composition of matter patents for those indications .... when they feel its worth it .
JMO
Kiwi
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ORBAPU

03/26/19 12:20 AM

#183199 RE: Jeffkad #183194

I posted this awhile back. Only one person on the board understood or commented. Probably a waste of time, but here it is again.

Ah yes, the BOB’s (Buy Out Boys) are at it again, opining how BP can save their timely, well deserved fortunes from this, “who the hell do they think they are”, pipsqueak company.

BP paradigm: Many drugs, one disease.

Amarin paradigm; One drug, many diseases.

People who work in manufacturing will understand the enormous significance of this.

Economy of scale is a key ingredient for competitive edge. Taken to the extreme, the cost to produce a product will approach the cost of the raw material as production quantity increases. Every time a new product is launched, it is front loaded with the nonrecurring cost for research, design, development, certification/qualification, and manufacturing lines, etc. Those costs have to be recovered on future sales margins. Those margins, in addition, have to cover profits to the owners and perhaps advanced development for the next generation product as well.

As you can see, all Amarin has to pay for in terms of recurring cost are trials for new diseases! Then, the more Vascepa produced to treat more diseases, the less expensive it becomes due to economies of scale. Moreover, all the nonrecurring cost to expand production is paid by their suppliers.

A master stroke if I ever saw one!

Chronic disease is the self propagating golden goose of Pharma. The drugs are expensive. The disease is never cured. The drugs cause dangerous side effects that must be treated with more drugs, also expensive and with their own side effects. Patients’ lives are extended so they can continue buying the drugs longer. What a deal!

My belief is that BP would focus on the RI cohort and bury Vascepa for other indications. Why would they threaten their existing expensive drugs with a cheaper alternative? No corporation is in business for the betterment of mankind, including Amarin. Amarin can make the maximum amount of money treating as many diseases as possible with Vascepa. Best part is that it doesn’t threaten the statin business at the moment.

The idea that big is always better belies the facts. Big makes a bigger splat when it collapses. SpaceX is outdoing Boeing and Lockheed in the commercial rocket business. Any hapless BA or LM employee unfortunate enough to suggest landing boosters after launch would have been laughed out of the room and sent to sit with the interns.
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BaaBaa45

03/26/19 3:01 AM

#183201 RE: Jeffkad #183194

Jeff, you have hit on a good point which is of relevance. On the negotiated date for generic entry ( see Teva/ other settlements) generic entrants will hit the market for that indication. Yes by that time Amarin may be a multi talented pony ( as opposed to a one tricker) but this will still be the same drug. Accordingly Docs could quite easily provide scrips for the generic “off label”.

The way round this would be for Amarin to tweak the formulation, and dose and create new IP to ensure that such substitution does not take place.



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sts66

03/27/19 1:27 PM

#183495 RE: Jeffkad #183194

The question of whether new trials and FDA approval for new indications can push patent protection out past 2029 has been a topic of debate here for several years, and nobody could answer the question - but a week or two ago, somebody did some research and discovered at least two drugs that got protection extended past original patent expiration by filing for a new indication - don't recall who posted it, but I know I responded to it as an "Aha!" moment - if you can search my posts, or figure out the keywords to use in a google search, you might find that thread. The question of what happens with Teva in 2029 if we get a new indication is still an unknown - AMRN made a deal, and they might have make a new one with Teva to tear up the old one, and it won't be cheap next time. Can't allow Teva to enter the market for the CVD indication and stop them from gaining patients for the new indication, because you can't prevent docs from prescribing GV off label for the new one.