Muscarinic receptor is listed first. Where have I heard that before? Oh yes the Muscinic receptor drug platform licenced from Heptares by Allegan for a ultimate value of $3.5 billion plus royalties. So remind me why the rumour of $3.25 billion offer by Biogen and counter of $7..50 by Anavex. Is that out of line given the Allegan/Heptares LICENCE only deal? There was only Phase One data on the Heptares drug. Allergan explained it as the Muscinic receptor activity was highly selective. But get this: A2-73 concomitantly activates M-1 and Sigma One.