Replies to post #214998 on NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

AVII77,

Thanks,

So, what do you do if you have a SOC patient who progressed, crossed over and received dcvax, and then it turns out the tumor regressed (psPD).

Was that regression due to DCVax on x-over or due to psPD from SOC (we know SOC causes psPD, we don't know if DCVax causes psPD).

How do you handle that? You can't suck the dcvax out of him.

How do you handle that? I think like in this case:

My dad is in the DC Vax L trial and just started the cross over arm about 2 weeks ago. He's received 2 injections so far and 1 next week since he's been in the cross over arm.

He started the trial around a year ago and was crossed over 2 weeks ago due to progression. At first Drs thought it was scar tissue but after 3 mris (6 month time frame), it became more clear it was slow tumor growth.

[sentiment_stocks]

So, what do you do if you have a SOC patient who progressed, crossed over and received dcvax, and then it turns out the tumor regressed (psPD).

Was that regression due to DCVax on x-over or due to psPD from SOC (we know SOC causes psPD, we don't know if DCVax causes psPD).

Because of the 3 months and two weeks screening required for this trial to look for any early progression as deemed by the trial criteria, there are likely to be very few if any control patients who entered the trial, then subsequently pseudo progressed due to chemorad. But if there were any, they will count as a control patient and thus wreak some havoc with the results.