My ill-informed speculation is that V-related weight loss might be due to reduced fluid retention related to reduced inflammation. This would imply that there is a max amount of weight loss possible with V. A weight-loss trial would be a short and relatively cheap (compared to R-It) study to do, similar to a DES study (but with the later making more mechanistic sense to me).
I think it boils down to is equal ratio of EPA/AA a signature for good health. EPA/AA test should become common place in the PCP's office. Prescription to patients who have unbalanced ratios.
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