It would seem to me that actual overall survival is more important than time to progression, whether it's pseudoprogression, or not. This trial has been going long enough to have some rather impressive number of survivors.
Perhaps someone knows, is pseudoprogression ever seen with SOC patients, or has it only been noted in people who received the vaccine. I've watched other companies involved with Oncological products and this is the first time I've heard of pseudoprogression.
I don't know what the data will show, but if someone who's alive in the trial today originally got into the trial many years ago, what difference will it make if at some point the clinicians determined that progression had occurred. Would it matter if it was truly progression, or pseudoprogression was determined if today the patient was still alive and living a descent quality of life.
During my treatment at City of Hope I've met many people who were given up for dead elsewhere, often decades ago. Most are currently cancer free and only coming in for an annual checkup, but some remain in treatment, what's important is they're alive. I wish I could say that my quality of life today was as good as before leukemia was found, but that would be a lie, but it's certainly still good enough to look forward to the future. I believe that's true for most who I've met at City of Hope. I do believe that patients should have the right to choose quality of life over longevity when longevity creates a quality of life that's unacceptable to them.
Gary
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