Replies to post #208931 on NorthWest Biotherapeutics Inc (NWBO)

[CogDiss 1188X]

Bevacizumab seems to have turned out to be a bit of a bust (though I don’t doubt it’s making billions). I know I had high hopes. Would be glad to be proved wrong on that if anyone one feels the need to post survival data. Actually would be thrilled to be proven wrong since an effective drug would be pretty useful!

I remember reading early phase results back in 2002? in which a couple of patients died and others had intestinal ulcerations or some such AE. Don’t remember how Genentech got around that - dosage maybe?

[meirluc]

longfellow, great point about Bevacizumab. It may not just be of academic interest. For example it would be important to know if there are significant survival differences between trial patients who received Bev and those who did not. Same with the Placebo group. Knowing whether Bev has a positive or negative affect on survival could allow for optimization of the DCVax-L treatment. It is therefore definitely important to look at that.

[survivor1x]

I swear I just recently read a publication that showed that BEV increased tumor mutations after usage(I can't find the article) and several other studies have shown that the greater mutations = increased efficacy in immunotherapy. Wish I could find that article on "AViSTaN"

http://science.sciencemag.org/content/348/6230/124


The below sort of hints at it. I can't find the 1 that points dierctly to increased mutations, I will keep looking.

https://www.raredr.com/news/genetic-testing-could-result-lifeextending-treatment-incurable-pediatric-brain-tumors

"Furthermore, Avastin (bevacizumab) appeared to cause immune cells to flood in to help eliminate their tumors, which indicated that they could be good possibilities for future immunotherapy. Bevacizumab works to block a tumor’s blood supply and direct the immune system to the cancer. The results also revealed that children whose tumors had mutations in the Mitogen-activated protein kinase (MAPK) network of genes benefited from bevacizumab alongside standard treatment."

It doesn't say why BEV caused the immune cells to flood, but I swear I read an article in the last 2 weeks that showed Avastin increased mutations and that could explain the influx of immune cells. I could be completely off base because I can't find the article.