Replies to post #171876 on Amarin Corp Plc (AMRN)

[Jt0082]

great find AND post AVI. thanks

[IslandOfMisfitToys]

"Hi, I'm hopeless conflicted and my knock-off trial is about to fail. I have no conscience and so throwing shade on a competitor comes naturally to me."

[ziploc_1]

AVll77: Nissen is the fireman of cardiology....he tends to put the damper on everything, especially if he is not personally involved in some way.

[ilovetech]

AVIl77,

The slight elevation in LDL-C and hs-CRP was observed in only a subgroup of the Placebo arm. I have a theory that could be tested by the data. At the start of the trial, patients may have become more inclined to succumb to their desire to eat far more than their treatment guidance. By virtue of being on multiple drugs, they may have felt a sense of invulnerability leading to gaining additional weight above their enrollment weight. According to the video, even the smallest BMI increase can increase inflammatory biomarkers.

I could see similar behavior from patients who schedule liposuction procedures. They have their BMI evaluated and documented before scheduling the procedure. Figuring they're going to lose all the fat the day of, some may binge on food one last time, causing them to gain more by the time they have the procedure done. This is something JL would know from his experience.

ILT