I am less concerned that "it works" than I am our ability to know it works, particularly w/AD. I predict if there are 10 patients in the trial that 3-5 will definitely show positive responses on some spectrum. The remaining will/may also show something but we will be unable to understand/measure their results accurately enough to declare anything on their behalf. IMO, those results will show over time there is some level of effectiveness for each one. The key metric will be Quality of life (QOL), every other thing being measured almost does not matter except to AVXL shareholders.
Eventually, AVXL will help everyone to understand true causal relationships in CNS diseases and by the time that happens BP will be more directly involved. Getting results now that can be accurately measured are critical to starting the process of learning. AVXL is an enabler and the leader.