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Replies to post #202592 on NorthWest Biotherapeutics Inc (NWBO)
12/08/18 12:56 PM
How much umbilical cord blood does it take to make a dose of DCvax?
How much umbilical cord blood does it take to make a dose of DCvax?
Looks like even in 2014 they didn't plan on using Sawston for DCVax.
NWBO investors are being played like a fiddle.AVII77
3.6 Movement Generation: First Principles
3.6.1 The proposal is a particular specialised type of manufacturing, and hence it is appropriate to consider the assessment of movement generation based on a first principles assessment.
3.6.2 The site is proposed to be operated by a contract manufacturer of medicines, but whilst most conventional drugs are manufactured from their constituent chemicals, the medicines produced are manufactured from human cells, and typically from the patients themselves. The medicines produced are “cutting edge”, and are part of a new class of medicines called Advanced Therapy Medicines.
3.6.3 Every medicine produced at the site will originate from human donor cells, and / or tissues. These will derive either from the patient, or a close relative, but there may be some from a bank of cells made specifically for one type of product including for example stem cell bank from donated umbilical cord blood. Another starting material is organs from the NHS Blood and Transplant Service that is unsuitable for routine transplantation but can be used as a “scaffold” for product development. Such products will be harvested across the UK, and transported to Sawston by specialised courier service.
3.6.4 The work that will be involved in the production of such medicines is undertaken on a small scale across the UK in major hospital, but this facilities would be the first “large scale” manufacturing facility. That said the work at the site is largely similar to that seen at Blood Transfusion Centres with the predominant traffic generation being by car for staff, and any professional visitors, and by the unit’s own vehicles for goods in and out for the most part.
3.6.5 It is anticipated that when fully operational, and in full occupation the site will employ the following levels of staff by skill type, and shift:
i) Manufacturing staff would work on two shifts from Monday to Saturday 07.30 – 16.30 25 staff 15.00 – 23.00 25 staff
ii) Warehouse staff would also work on two shifts from Monday to Saturday 07.30 – 16.30 4 staff 15.00 – 23.00 4 staff
iii) Site security staff on three shifts 07.30 – 16.30 1 staff 15.00 – 23.00 1 staff
iv) 5 scientists for product development on Monday to Friday 09.00 – 17.30
v) 5 office / support staff on Monday to Friday 09.00 – 17.30
3.6.6 Table 3 shows the arrival / departure profiles based on a first principles assessment. The arrival / departure profile assumes that staff will arrive and depart within the quarter of an hour before and after their shift start respectively. As a “worst case” assessment, the profiles assume the following modal split:
Car 94%
Cycle 4%
Walk including public transport 2%
These values are from the Sawston Business Park TA. There were no values provided for by public transport access which are taken as being included within the walk percentages.
3.6.7 The profile also indicates an assessment of parking accumulation which indicates that between 14.45 and 16.45 that there may be a need to accommodate the parking demand of two shifts of 65 vehicles in total. The overall car parking provision including the main car park would be adequate to accommodate the demand by staff, and visitors.
3.6.8 In addition to the staff movements, there are likely to be regular, and irregular goods vehicle movements as follows:
Delivery and pick up 20 per day by transit sized vehicle
Delivery by box van 12 per week
Cryogenic delivery trucks 2 per week (once every 3 days)
Domestic refuse removal 1 per week
Clinical waste removal by box van 3 per week
3.7 Traffic Distribution
3.7.1 The vehicular traffic distribution used for testing purposes if appropriate will be identical to that of the TA prepared for the Sawston Business Park planning application for cars, and goods vehicles as follows:
Cars HGVs
a) To / from Whittlesford Road 20% 0%
b) To / from A1301 then
To / from the north 20% 33%
To / from Sawston 20% 0%
To / from south 40% 67%
