Replies to post #173541 on Anavex Life Sciences Corp (AVXL)

[nidan7500]

Hmm.. would gene therapy be necessary if normal sleep were restored and neurogenesis became a more natural process?

I like the sound of restored homeostasis. Maybe simplify life a little huh.

[nidan7500]

Repeat Xena linked pub. PDD trail and use of Actigraph may end up being significant value added device. If the device works as advertised in this trial (in addition to typical sleep measures) then it all fits well with the Precision Medicine initiative and our recent Consortium of WW leaders.

Sleep Fragmentation

Sleep fragmentation is probably the most common nocturnal complaint in Parkinson’s disease. Several studies analyzing sleep patterns in Parkinson’s Disease have found that the sleep pattern is more frequently interrupted and that the amount of time spent in slow-wave and REM sleep (the deepest and most restorative phases of sleep) is significantly less than that of age-matched adults without Pakinson’s. This type of sleep disturbance may be associated with a greater susceptibility to medication-induced hallucinations as well as excessive daytime sleepiness.

https://www.ncbi.nlm.nih.gov/pubmed/24218292
IMO, it is also worth noting that such new equipment in use in any trial will tell one what is NOT and issue.In other words, if there was any debate that sleep was NOT and indicator of consequence then ERP data closes the point w/solid quantitative data. And, these kinds of trials are reproducible. Try that w/a survey.