Replies to post #162458 on Amarin Corp Plc (AMRN)

[Pyrrhonian]

From those papers there is no way to tell the magnitude of effect of MACE increase / reduction from a change of LDL-C in the 75-84 mg/dL range.

That’s not correct. Actually I cited a study in a previous post that accumulated data with thousands of patients per arm and showed very predictable avg % drops in those on various doses of various statins. There is a paucity of data on LDL-C reduction in those with levels around 100 at baseline, but it is out there. Comparatively it is a less robust decline on 10-20 mg doses of atorvastatin and other low doses of other statins. It’s simple deduction from there. 70% took equivalent to 10-20 mg atorvastatin and 30% took 40-80 mg in R-IT. That’s not debatable. All had to have LDL-C between 40-100 mg/dL at baseline. The median and mean around 75. Also not debateable. Boom. It’s easy from there. Pre-statin their LDL-C mean is near 100, and hsCRP somewhat > 3.2.