Replies to post #162173 on Amarin Corp Plc (AMRN)

[sharinky]

Thanks to John Cappello and others for engaging Dr. Deepak Bhatt in great twitter conversations.


Dr. Deepak L. Bhatt
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@DLBHATTMD
10h10 hours ago
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Replying to @JrwilliWilliams @JohnCappello @DrDerekConnolly
Given how well icosapent ethyl performed in patients with diabetes, metabolic syndrome would be an appealing population for a next trial. Not sure a head to head trial would be feasible given current pricing of PCSK9 inhibitors though.
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Dr. Deepak L. Bhatt
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@DLBHATTMD
14h14 hours ago
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Replying to @ra_fun @DrDerekConnolly
I view statins (LDL reduction) and icosapent ethyl (multiple mechanisms of benefit) as complementary approaches. However, if a patient cannot take statins due to side effects, I would not deny them icosapent ethyl, even though we did not study that. A combo pill seems brilliant.
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Dr. Deepak L. Bhatt
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@DLBHATTMD
14h14 hours ago
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Replying to @JohnCappello @DrDerekConnolly
While icosapent ethyl is a prescription drug and a highly purified ethyl ester of EPA, it is ultimately derived from nature. As such, I believe it has multiple therapeutic effects. Probably a Nobel prize in there for a basic scientist who can unravel exactly via what mechanisms.
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