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pgsd

11/13/18 10:49 AM

#197212 RE: Rkmatters #197209

Exactly RK. I think you have had an excellent take on most things and appreciate all the hard work that certainly better informed my DD. If the company wish to release results before March it will save me getting more gray hairs also and that has to be good.

flipper44

11/13/18 11:01 AM

#197216 RE: Rkmatters #197209

I see that they told us they would continue the trial to the end with their August 2014 disclosure. -- RK



Umm, they told us in December 2014 that they'd reach topline in early 2016.

They didn't tell us jack in August 2014. They did not define "end" in 2014.

They told us the primary endpoint was their goal, and they changed that in October 2015 to move it out to October 2016.

Then they set 233 OS as the trigger to final analysis. Then LP and Les thought 48 months past median enrollment or 36 months past last enrollment looked interesting.

Now they are not stating anything, but one can read from the financing, and who it is that is financing, that they are likely telling him and other angel investors that their new deadline is March 2019.

That would allow a freeze from about today, collection, another scrub, data lock and topline.

doingmybest

11/14/18 7:01 AM

#197355 RE: Rkmatters #197209

Rkmatters,

I hope all is well with you.

My only alternative thought on timing is whether NWBO has shifted from 36 mos from randomization per protocol to 36 mos from surgery given the published paper analysis referenced from surgery. Since the reference point became surgery in this paper I wonder if they received permission from RA's to define their timing as such.