Feedback Web results Arthritis vs. Arthralgia: What's the Difference? - Healthline https://www.healthline.com/health/rheumatoid-arthritis/arthralgia Dec 1, 2016 - Arthritis is “inflammation (pain with swelling) of the joints.” The CCFA notes that you may experience arthralgia in different joints in the body, including the hands, knees, and ankles. It also explains that arthritis can cause joint swelling and stiffness as well as joint pain like arthralgia.