Replies to post #152519 on Amarin Corp Plc (AMRN)

[ggwpq]

EPANOVA, failure to launch!

[IgnoranceIsBliss]

They wish

DHA is like rat poison. It blocks EPA, raises LDL-C, and in some cases I’ve heard, it has other horrible side effects like making you vote Democrat, and rooting for the Patriots.

I’m with Pyrrh on this one — EPA good, DHA bad.

[SonamKapoor]

JT: I guess we have to wait for Oct next year re: STRENGTH. I agree with your last two sentences.

I've had it explained to me that the chemical forms are like various generations of tech with a slide showing at the base of the pyramid natural TG forms for the EPA/DHA. So, kind of like this--

4G: Emulsifications/PLs
3G: PLs, FFAs
2G: EE, rTGs
1G: natural form TGs

There's crossover between the tech generations and no consensus on the levels & which is better - all debatable. Eating a sardine would be the lowest form of tech in other words - but, its not "worse" & may also be much better than the later "tech" for the average healthy person because we would get all the peptides and other natural substances according to registered dietitians. (Like allergy "tech" - Benadryl is 1G (indiscriminate effects) while Claritin/Zyrtec/Allegra are later versions)

The board debated this topic in Feb 2018 with the posting chain
DitD: 122238
JL: 122245

Also, I can't remember the post # maybe somebody else does where the statisticians here on the board posted/commented on the wide error bars on I believe this study: 47 person emulsified cod liver oil study Dr. Calder reviewed and summarized 12 studies published between 1990-2015 and their showings on which form was "better" or "tied" on Slide 20 and went on to quickly review his unpublished small study with Dr. West on emulsified forms. Calder ppt

This has been covered in Nutra Ingredients Nutra magazine Aug 21 2018 cod liver emulsification study I like Dr. Harris' quote at the end to which form is better based on speed of uptake "So what?"

To JL's point - it first matters to marketers. GSK sponsored that cod liver oil emulsion study which makes sense. Everybody is looking for the edge with a new story to spin for growth, just like every other industry. I agree with Dan and HDG and others on here regarding AMRN which has an ideal Hollywood set-up - lipid regulator ver. 2.0 in other words, like another Star Wars movie. Investors don't have to think too hard - they figure its going to be a blockbuster (like Lovaza was).
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I also agree with JL post #151371. It's about reducing systemic inflammation as UC Davis did with a horse that had laminitis and was dying which then started walking around again and was fine after treatment (but these were DHA epoxides):

Dr. Bruce Hammock horse article

Capt. Joseph R. Hibbelin, MD has done a lot of work on SI reduction in the neurosciences with Omega 3's as well (too little DHA in the brain and all the mental health issues it seems to cause). For example, people who consume high levels of fish regularly are 20% less likely to have major depression.

The arachidonic acid cascade really seems to be correlated with our poor Western diet in terms of Omega 3s for a lot of people. I've read Dr. Joseph C Maroon's book "Fish Oil: The Natural Anti-Inflammatory" and it covers much of this same material. Amazon - Dr. Maroon fish oil book He was/is still? the Pittsburgh Steeler's team neurosurgeon (U Pittsburgh).

Anyways, that's what I've been able to glean.