Theoretically, site activation duration can be reduced to the time needed to activate a single site—100 days on average. (With improved planning and execution, that average can be reduced as well.) Since site activation uses two-thirds of enrollment cycle time, a 50 percent reduction in site activation time would reduce enrollment cycle time by 30 percent. And a 30 percent reduction in the current median enrollment cycle time of 490 days would amount to more than five months. I believe this is a number attractive to anyone in drug development.