Replies to post #191084 on NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Cancer science is currtently unnecessarily bottlenecked.

I have tried to understand why it took so long to perfect DCvax-Direct after the first trial. As Dr. ML has explained in a completely different setting, not associated with this platform, you need to make the pivotal trial go forward with the final product manufacturing process if at all possible, otherwise you can run into real hurdles -- like having to add preclinical bridge trials, and/or more clinical trials.

Nonetheless, IMO, DCVax-Direct is now ready to go for a pivotal imo. I think NWBO's lack of major resources (and/or external attacks and/or perhaps even some management ineptitude) grounded/delayed societal progress toward curing some cancers. It's very sad imo. I'd think we are at least a year or more behind where we should be for initiating Direct trials.

[XenaLives]

Source please... this board isn't easy to follow!

[flipper44]

Link included, this slide should have been distributed out more than a year ago. Instead, back then, we were given a slide with only the top 1/3 of patients, which was target practice for AF. Now we have a complete slide, except without method A and method B differentiation. That might be in respect for a couple patients who are doing well, even though they received method A. Who knows, but had DCVax-Direct been all method B (aka: four hours less activation time for better results), this chart would have been even more amazing than it is now/below -- much more so, imo. Still, method A really did, imo, act like an active control. Dr. Bosch is right about that. (In the DCVax-L trial, I think that at least the first 2/3 of the first 38 patients enrolled will also act like an active control of sorts.)

Anyway, here again is the DCVax-Direct survival chart which subtracts expected longevity from the calculus.
https://www.nwbio.com/wp-content/uploads/2018/08/I-O-Summit-Presentation-FINAL.pdf

[flipper44]

BTW, NWBIO has removed this helpful slideshow from their website, even though it is supposed to be there. Instead when you try to download it, you get a "404" error.