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Leprecon7777

09/10/18 12:52 AM

#188816 RE: flipper44 #188815

Both sides... but I do not know the split.

However several months ago when I was doing some analysis; the 108 alive number did not make sense to me...

331 - 108 - 11 assumed LTFU = 212 events by March.

NWBO stated that the trial endpoint of 233 OS events would be reached in July. So 21 events were required in 4 months??? Seems to be way too many to me!!!

And based on my modeling of the NWBO survival curve, there should have been more events by March. It made me question if NWBO was including the LTFU patients in the 108 number.

As further evidence, consider that in June NWBO said that there were 100 alive. 331-100 = 231 events and NWBO also said the event rate had slowed to 2 events per month Thus their projection of July would be correct IF NWBO was including the LTFU in the number 100 alive.

Thoughts???