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highwayman4life

08/31/18 10:48 AM

#188001 RE: photonic5 #187993

Yet...there’s something behind these GBM patients living longer and this trial having to carry on for so long. Efficacy and approval would disrupt a market. The big dollars of status quo are fighting hard against it.


It's what I and many others continue to focus on! It's not even worth getting into managements shortcomings...hoping science will prevail here.

GLTA
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iclight

08/31/18 1:12 PM

#188027 RE: photonic5 #187993

Yeah there is something behind all the patients living longer.

Of the 960 actual glioblastoma patients they screened, they kicked out 250 for progressing. When you read a 5 year survival rate for glioblastoma, that doesn't exclude patients who progress early. Not to mention all the other patients that didn't pass the screening, many for various reasons that would have had the "not living longer".

It's a classic selection bias issue that will end the same way as CLDX, with the control arm greatly outperforming expectations.

Just look at this screening flowchart again.