Replies to post #162922 on Anavex Life Sciences Corp (AVXL)

[roygbiv]

The Sig-1R in lipid rafts is upregulated after a hypoxic episode. Trafficking is enhanced in cells activated by a Sig-1R agonist and is depressed by an antagonist (14). After experimental stroke, the Sig-1R is strongly expressed in reactive astrocytes surrounding the infarct and can also be found in the extracellular space. This suggests that Sig-1R may promote the release of exosomes that support the scar-forming and/or plasticity-promoting processes in recuperating neurons (Fig. 1).

Thanks for posting. GL