Doc, first of all thanks again for your continuing guidance. Would you comment on the strength of this paper/the body of knowledge represented by this group and what this all means? We have seen the amyloid Thesis fade despite actions of BIIB, and including the embarrassing AAIC2018 press coverages. With that, is this now the new awakening as Precision Medicine hopefully brings some light to an other wise dark field? Are we seeing the "sea change" needed to make progress finally? In that context, is AVXL in the leadership position it appears to be in?