While I applaud DM for getting approval to start a thorough, comprehensive, and statitically meaningful drug trial, this is perhaps what has taken some of the air out the balloon. Even though we are in the early stages of CNS precision medicine, the statisticians still require a certain number of trial participants in order to allow for it to be powerful. So while we may have precision medicine, the testing needed to prove it effective will still prove ti be more expensive than DM hoped. A trial this size, scope, and duration will require more resources than originally thought. AND, we still have 2 more trials (Rett & PD) that have not been announced. We will either need to dilute, partner, or scale back some of the other trials. I think this is why the SP is responding the way it has today—EUPHORIA has given way to the economics of running these trials.