Replies to post #35428 on Intellipharmaceutics International Inc. (IPCI)

[WeeZuhl]

It's quite much enough if it reduces effect of two tablets to effect of 1½ conventional tablets.

It doesn't. PODRAS doesn't do anything at all until the 3rd tablet. This is why it doesn't prevent oral abuse. I've posted the graphs and the photos from the PODRAS patent multiple times. Look it up. Also, remember, PODRAS has to work exactly right every time, or it is useless. And I don't mean it has to prevent overdose every time. I mean every time a legit user takes a legit dose, PODRAS has to work exactly right. The antacid layer has to be completely destroyed then acid-releasing layer has to be completely uncoated before the tablet passes into the small bowel where the pH is too high to trigger the release. If it doesn't, then the legit user gets none of legit dose. For oxy, that means acute withdrawal with nausea, vomiting, and acute pain for starters. For other meds, it could be even worse (seizures? death?). This is a very tall order considering the common variation in stomach acid can vary by 1000X. Some people take strong acid-inhibiting meds. Some people take meds with empty stomach (fast transit) and some people take meds with full fatty meals (slower transit but higher pH). That's why it will never pass a bioequivalence study for any drug and probably why it hasn't made even 1 small step in development in more than 3 years.