Replies to post #174209 on NorthWest Biotherapeutics Inc (NWBO)

[evanstony]

half of the world is sleeping now... it will take days for this to be assimilated ... not everyone is glued to the news on NWBO... It will have a bigger impact after ASCO... IMO

[learningcurve2020]

Well, at least the trial appears legitimate.

Seems like some heavy exclusion criteria. And what the heck does this mean?

>>Patients with radiographic evidence of disease progression at baseline were excluded, as they have also been excluded in other recent trials for newly diagnosed glioblastoma [4, 21, 24].

[MI Dendream]

Final randomization seems to indicate that the last 30ish patients enrolled after the halt were put on treatment only rather than randomized to placebo. This confirms in my mind that the halt was due to an efficacy signal and regulators required randomization to placebo to be stopped. The trial continued but it was no longer ethical to randomize patients to the inferior arm.

Great news! Big days ahead