This may be too much for you. The drug sponsor is Paul M. Ridker, MD Director of the Center for Cardiovascular Disease Prevention Eugene Braunwald Professor of Medicine He is not a rheumatologist. He is not going to tell another group of specialists how to practice. He will publish the results and leave it to the rheumatologists to adjust their practice if necessary.
Here is a website for you with facts. This study could fail but sponsor could still want patients to remain on the drug until trial is locked down and reported.
www.fdable.com put in methotrexate click on Role Code - primary suspect and Outcome code - Death.
The search will come back with this -
Searched for Adverse Event Cases with drug names containing the term: methotrexate AND with the drug's role code reported as: Primary Suspect and found more than 10,000 results.
Nasty stuff. You can play around with this, check out Vascepa and see how it compares.
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