I do not need to - both of them are way smarter than me
FDA knows this and as such still not even approved IND for Rett
AVXL knows this and as such they are struggling to find right way to justify and present protocol for AD next trial which can be approved by FDA. If they knew, they would not keep on talking about starting the trial for more than 1 year - look at many otc biotech and how fast they get their IND and protocols approved.