Replies to post #146472 on Anavex Life Sciences Corp (AVXL)

[falconer66a]

Depends; Not Much

Whether Anavex 2-73 might disable specific neurotoxins, or subsequently restore nerve function depends on just how the neurotoxin worked its damage.

Most bind to or disable essential enzymes. With that, normal neuron chemical processes are interrupted; the nerve no longer functions and associated, controlled organs or systems are disrupted.

I'm not aware of neurotoxins that dissemble the mitochondrion/endoplasmic reticulum connection. Anavex 2-73 would be able to prevent that, or restore the connection, perhaps.

Would not be surprised if some post-docs have done some quiet, in-house testing of this on lab murines. Not the kind of thing, however, that should be in the public domain.