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dewophile

03/05/18 10:38 AM

#217689 RE: poorgradstudent #217676

I think newer drugs like axitinib are the real competition



but Axitinib failed in first line vs sutent.

I also think comparing ORR w TKIs vs PD-1 based tx is not reflective of odds of success given what seems to be better durability of the latter responses (just based on fact PD-1 combo has already bested sutent in first line)
so long story short I am more confident of epacadostat (and other IO combos) in RCC vs any TKI monotherapy (although TKI plus PD-1 could be tough to best as you point out)