Nidan -Is not the Insomnia, Agitation and Anxiety market BIG? Any idea how big it really is? No doubt we are getting ready to hit HOMERUNS, not singles!
I agree, we'll load the bases with a successful P2/3. Endpoints are extremely achievable IMO.
Then P4 trials can be done for cognition, prevention, early stage, late stage, all manner of variants. Governments and clinics will willingly participate because they will know that at minimum, they are improving the lives of these patients.
How many will be "super responders" need not be known until after approval.
Does it work in Depression? Does it work in TBI?
A successful P2 in Parkinson's will have the medical establishment wondering.
Then we will knock it out of the park and send Big Pharma home in disgrace.