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DewDiligence

02/24/18 5:02 PM

#217470 RE: mcbio #217469

...rapidly reducing viral loads to undetectable levels would seem to be what you would want in such a trial.

True—provided that the virus doesn't quickly become resistant to the drug.

I'm not saying ReViral's RSV fusion inhibitor won't work well, but rather that its MoA leaves a smaller margin for error than an N-protein inhibitor such as ENTA's, and it's more likely (IMO) that it would need to used in a combination regimen.

There may also be differences in safety/tolerability to distinguish the various RSV drugs in development.