Replies to post #158700 on NorthWest Biotherapeutics Inc (NWBO)

[survivor1x]

What happens when you assume non proportional hazards (a curve vs a line)?

[sentiment_stocks]

Thanks for giving me that p-value if control were at 20 months and treatment at 28 months - which would be .015 - and that result would be stat sig, right?

You indicated that you think patients with EGFRv3 expression is a negative prognostic indicator.

This paper suggests differently, although they admit they diverge from previous studies. In the discussion section, the paper cites,

Major results were as follows: 1) the presence of EGFRvIII in GBM tumors correlates with longer OS.

and

In summary, this study shows that EGFRvIII is a molecular predictor of longer OS in GBM patients treated with surgery followed by adjuvant radiotherapy and TMZ. This effect may be ascribed to a better response to TMZ and to a lower repopulation potential by the EGFRvIII-positive GBM cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257186/

Could you indicate which sources you are referencing at to make you think they will do worse? Because back in October, you thought this same above linked paper, which indicates EGFRv3 was a "positive prognostic indicator" boded well for DCVax, if it were compared to the Rindo control arm. What has changed since then, or do you not accept the findings of that paper?