Replies to post #154924 on NorthWest Biotherapeutics Inc (NWBO)

[SpursFan08]

So it looks like at the latest the journal was submitted in November and could take 9 months which is August. Looks like no significant news or clinical update most likely until then so wait we will!

[VuBru]

233 was chosen because that was the minimum needed to have adequate statistical power for OS. Going beyond that means greater power, which is not at all a bad thing.

[Evaluate]

233 happens to be the 70% mark of the 331 patients. (Just as 244 was 70% of the 348 patients)

I noticed when Dr Bosch last spoke at conference, that he was starting to mention "a minimum of 233" .... so that is when I started to get an inkling that they were considering going beyond the 233 event threshold. I think I posted something to that effect back then.

[doingmybest]

While you are basically correct the need for IO therapies to demonstrate long tail benefits has become the driving factor in such trials, particularly with the first approval of a therapy.