Good point but H/W innovation allowed new S/W systems to be developed, although after a while it was not clear who was leading who. The whole learning process was dependent on working systems integration. Eventually S/W will allow medical science to customize treatment of CNS diseases(like cancer research is doing now). In some way (IMO) this is where AVXL is with A2-73 platform/thesis but it is just the beginning. They must prove/demonstrate the value before we run out of runway. Which, IMO is why he chose RETT as #1.