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biomaven0

12/03/17 12:23 PM

#215599 RE: dewophile #215597

>>also probably inhibits collagen PH

Might even be a good thing - that has been proposed as a target in fibrosis:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634087/

But again, intermittent inhibition is quite possibly different from continuous inhibition.


poorgradstudent

12/03/17 1:24 PM

#215600 RE: dewophile #215597

FGEN:

The part that shows roxadustat, in addition to its intended inhibition of HIF PH, also probably inhibits collagen PH



Right, I got that. But what do you think is the negative in vivo consequence of this? I'm not being obtuse, I just don't want to miss anything.