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dewophile

12/03/17 5:23 PM

#215608 RE: poorgradstudent #215600

The article suggests compromised immunity as one negative consequence from interfering with the complement cascade, but I am sure you got that too. The article did bring me back to this comment from GSK regarding the competitive prospects of their HIF stabilizer:

We had molecules before that inhibited collagen-4-hydroxylase. I can tell you that
you don't want to do that: that causes a cardiac problem in animals and we think that is an
important thing to completely avoid



https://www.gsk.com/media/1442/randd-day-transcript-full.pdf

Now to be clear I don't think there is a large risk here, and Peter makes a good point regarding dosing. But after a run up I personally decided to play it safe and take profits (which of course means the stock is destined to go up ;)