Replies to post #128760 on Anavex Life Sciences Corp (AVXL)

[falconer66a]

New, Disruptive Things Discounted At First

...but why doesn’t Wall Street and the scientific community come out and have great things said about these results.

I’m not expecting any jump in AVXL prices on Monday. If anything, they will decline a bit. If the new data are so positive (which, they are), just why, then, won’t The Street and the medical community start espousing and promoting Anavex? On the face of it (even more so, beneath the surface), Anavex has serious, viable solutions to any number of central nervous system diseases, with new, unique, proprietary mechanisms of action that work with minimal side effects. Why no big positive reaction?

Check the history of science and medicine. The scientific and medical communities simply prefer that things stay as they are, progressing slowly and incrementally, building only upon what is clearly taught, known, and proven. Ideas and concepts outside of accepted, common knowledge, is almost universally discounted and rejected. It can’t be true. It runs against everything that the best medical and scientific minds already know to be so. The scientific endeavor is primarily to ever more accurately (say, “statistics”) prove existing explanations for existing phenomena. Explanations outside of existing bodies of taught knowledge are, de facto, not recognized. Science and medicine have the explanations and answers for most phenomena. New explanations and protocols are always, at least at first, held with the greatest skepticism, even derision.

It has been the case for centuries. Look up Semmelweis. (https://en.wikipedia.org/wiki/Ignaz_Semmelweis) Read how long it took the medical community to subscribe to his explanation of peurpural fevers from contaminated physicians’ hands. Thousands upon thousands of women died after childbirth because the established medical community rejected, would not embrace Semmelvweis’s simple protocol to have physicians thoroughly wash their hands before attending to a childbirth.

It was the “germ theory,” where a few knew for certain that bacteria (“germs”) existed all over, and most were pathogenic, causing any number of diseases. Until Lister, Pasteur, and others “proved” asepsis as disease prevention, the medical community went on for decades continuing to believe disease was caused by “re-breathed air,” in small interior spaces (hence, the tall ceilings in 19th-century building; supposedly healthier, less re-breathed air).

Same thing with Alexander Fleming. He found an antibiotic, penicillin; but it took over a decade (and mostly, the casualties of WWII) to prompt its commercialization. The medical community was not supportive at all. A weird anomaly of unclean labware, only, it was thought.

I could go on for many pages. Einstein’s early work was dismissed. It didn’t at all fit with “real physics,” the Newtonian world of academic physics.

So it is with Anavex. Everything is wrong about the company. Nothing fits with accepted, known science, medicine, or commerce.

Everyone knows that billions have been spent on effective treatments for Alzheimer’s, and each has failed. The vast body of Alzheimer’s researchers (PhDs) know for certain the only approach is to, somehow, eliminate or prohibit beta-amyloid plagues and tau-tangles. They know, for certain, those are the root, exact cause of Alzheimer’s. Any other target is wrong; can’t work.

Anavex targets something few know about, for which there is minimal information, the effects of a dissembled endoplasmic reticulum/mitochondrion interface. Anavex has this flaky notion (unproven in the science literature, never taught to the PhDs) that re-connecting the ER with mitochondria restores normalized neuron function. And, they have a unique, proprietary set of molecules that do this.

Not only that, they do it safely, without side effects. Every brain cell researcher knows offhand that virtually all drugs affecting the brains and nerves (“neurotrophic”) have bad side effects. Anavex’s Australian data have to be suspect.

Anavex challenges everything known and believed about Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, Rett syndrome, and all the others the company claims to have efficacy against. Too good to be true. Too far out in the medical left field.

In fact, a short consideration of the implications of an Anavex success is rather terrifying, professionally. What happens to giant multi-million dollar neurology clinics if most of the major CNS diseases can be prevented (treat early with Anavex) or easily controlled (just pop 50mg of Anavex 2-73 with breakfast each morning)?

I project the Semmelweis Effect applying to Anavex. It will take a while for all three communities, the investment community (retail and institutional), the practicing medical profession, or the medical training profession (med schools) to accept Anavex.

Let’s see how this all develops. Like penicillin? Like asepsis? Like quantum mechanics? I fear so.