I'm comparing to the charts I found, which I believe are optimized dosage. I would compare to an optimized dosage for 2-73, but that isn't available. There is just the MMSE chart for all patients.
I'm looking at the whole thing. I don't put that much statistically into that uptick after 52 weeks. People seem to be putting a lot into changes of less than a point on the MMSE, and with a small sample size at that. To me, the overall picture from the 2-73 MMSE chart, within the small range on the MMSE it is operating, is that it is fairly stable over 12 months. The same for donepezil. As rubyred pointed out, it does decline (like 2-73) after a month or couple months. But we're talking about movement within about 2 points on the MMSE over 12 months, and a small fraction of 1 point over each 4 weeks. It's all small movements. But when looking over more than 12 months you really do see that the decline is exacerbated and continues unfettered, which is why I want to see the chart for 2-73 over a longer period as well. Preferably, of course, with dose optimized for a true comparison.
I don't know about the dzp affecting 2-73. There's not enough data. Does it even say how many patients were on both 2-73 and dzp versus just 2-73?