Replies to post #115786 on Amarin Corp Plc (AMRN)

[golf stud]

This also brings up a question as to how much different people should take a day. Should a 110 ib lady take the same amount of vascepa as a 220 lb male?

[jessellivermore]

UFO...

Quote: "Basic question I guess is how much EPA is too much?"

Let's think about it...The USA deaths from coronary heart disease is 78 deaths per 100,000 annually and the USA death rate from Alzheimers is 45 deaths per 100.000 annually....

If we compare this to the Jap figures of 30 deaths from CHD. There is no mention of Alzheimers in the jap numbers (think this might be an EPA effect?) stroke is 8 deaths higher per 100,000 in Japan. Infection rates pneumonia and influenza are much higher 30 per 100,000... lung cancer is higher in the USA...35/100K vs 21/1ooK..(? another EPA effect more Japs smoke)...

On the whole looks like you would have to take a huge amount of EPA to eliminate the benefits of EPA to the USA diet...Only in Japan where most people have Japanese level EPA/AA ratios do you run the risk of raising your risks above the populations...

":>) JL

[marzan]

One crooked Advisory Committee cardiologist from Colorodo I guess Dr. Hart (I forgot his name) or someone raised this Bleeding question during the Anchor Adcom and FDA responded saying they didn't find any safety issues with V taking 4gms a day. This has been dealt in the past, imo. And I think Zum has posted a link for a literature How much EPA is so much enough.

[ralphey]

UFO .. In general increasing dosages do not continually increase benefit in a linear progression

For example if you double your dosage of your BP pill you do not double its lowering capacity. Most benefit from medications occur within their initial dosages - increases after that have diminishing returns and eventually will turn into negative side effects